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10septembre

Potassium and malaria

Artemisia annua rich in potassium

Potassium, the most abundant cation in the human body, regulates intracellular enzyme function and neuromuscular tissue excitability. Serum potassium is normally maintained within the narrow range of 3.5 to 5.5 mEq/L. During malaria infection the cytoplasm of infected erythrocytes is poor in potassium and rich in sodium, a drastic change compared to non infected erythrocytes. H. Ginsburg,S. Handeli, S. Friedman. Effects of red blood cell potassium and hypertonicity on the growth ofPlasmodium falciparum in culture. Zeitschrift für...

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10septembre

Beta-hematin inhibition a key weapon against malaria

Artemisia infusions inhibit hemozoin

Beta-hematin inhibition and antimalarial properties Recent results obtained at the AlQuds University in partnership with IFBV-BELHERB from Luxembourg show that freshly prepared infusion of Artemisia annua or Artemisia afra is stronger than chloroquine in the inhibition of beta-hematin (hemozoin) formation. In infected erythrocytes, the malaria parasite generates large quantities of toxic ferri-heme, the Achille’s heel of Plasmodium. With hydrogen peroxyde which is present in all living beings, heme forms aggressive radicals which kill...

Posté dans Informations

10septembre

Beta-hematin inhibition a key weapon against malaria

Artemisia infusions inhibit hemozoin

Beta-hematin inhibition and antimalarial properties Recent results obtained at the AlQuds University in partnership with IFBV-BELHERB from Luxembourg show that freshly prepared infusion of Artemisia annua or Artemisia afra is stronger than chloroquine in the inhibition of beta-hematin (hemozoin) formation. In infected erythrocytes, the malaria parasite generates large quantities of toxic ferri-heme, the Achille’s heel of Plasmodium. With hydrogen peroxyde which is present in all living beings, heme forms aggressive radicals which kill...

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10septembre

Artemisia campestris, santonin and worms

Anthelmintic properties of Artemisia campestris

200 years ago, in 1830 the anthelmintic properties of santonin were discovered, simultaneously by Dr Kahler in Düsseldorf and Dr Alms in Mecklenburg in a plant from Turkestan, Artemisia cina. Its presence, although at lower concentrations, was later found in Artemisia maritima, Artemisia gallica, Artemisia absinthium, Artemisia campestris, Artemisia sieberi. Non declared author, Berichte der Deutschen Chemischen Gesellschaft , 1867, Vol 6, 875-167 Stanislao Cannizzaro is known widely for his document on santonin which he presented at...

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10septembre

Plasmodium and the apicoplast

apicomplexan parasites

The apicoplast is a plastid organelle, homologous to chloroplasts of plants or algae, that is found in apicomplexan parasites like Plasmodium or Toxoplasma. In hinsight it seems incredible that such an organelle could so long have concealed its identity in parasites that have received as much scientific attention as Plasmodium Chakraborty Arnish, Understanding the biology of the Plasmodium falciparum apicoplast; an excellent target for antimalarial drug development, Life Sciences (2016), doi: 10.1016/j.lfs.2016.06.030) Apicoplast...

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Citation

L’homme nous passionne, sa diversité, ses histoires, ses savoirs, ses ignorances, sa compréhension du monde

Alexandre Poussin

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