Informations

11septembre

iron is bad for malaria and other diseases

iron chelators in malaria

One of the first mistakes of Western medicine in Africa was the iron supplementation to the Somali nomads in 1968. Blood analysis of these nomads had shown that according to European standards they were suffering from anemia. Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. Br Med J. 1978 Oct 21;2(6145):1113-5. But iron administration was associated with a significant increase of the disease it was supposed to suppress and even to reactivation of pre-existing...

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11septembre

Para-aminobenzoic acid and folates enhance malaria

PABA plasmodium

Malaria, folates and PABA : beware Folates combine three molecules : pretidine & para-aminobenzoic acid (PABA) & glutamate. They were discovered around 1940 and first isolated from spinach leaves. The term folate is derived from the latin word folium. The malaria parasite has a unique feature of being able to salvage exogenous folate derivatives and/or synthesize them de novo. Due to its high rate of replication, the parasite has a high demand for folates. Folate metabolism is the target of several antimalarials. Food fortified with folic...

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10septembre

Potassium and malaria

Artemisia annua rich in potassium

Potassium, the most abundant cation in the human body, regulates intracellular enzyme function and neuromuscular tissue excitability. Serum potassium is normally maintained within the narrow range of 3.5 to 5.5 mEq/L. During malaria infection the cytoplasm of infected erythrocytes is poor in potassium and rich in sodium, a drastic change compared to non infected erythrocytes. H. Ginsburg,S. Handeli, S. Friedman. Effects of red blood cell potassium and hypertonicity on the growth ofPlasmodium falciparum in culture. Zeitschrift für...

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10septembre

Beta-hematin inhibition a key weapon against malaria

Artemisia infusions inhibit hemozoin

Beta-hematin inhibition and antimalarial properties Recent results obtained at the AlQuds University in partnership with IFBV-BELHERB from Luxembourg show that freshly prepared infusion of Artemisia annua or Artemisia afra is stronger than chloroquine in the inhibition of beta-hematin (hemozoin) formation. In infected erythrocytes, the malaria parasite generates large quantities of toxic ferri-heme, the Achille’s heel of Plasmodium. With hydrogen peroxyde which is present in all living beings, heme forms aggressive radicals which kill...

Posté dans Informations

10septembre

Beta-hematin inhibition a key weapon against malaria

Artemisia infusions inhibit hemozoin

Beta-hematin inhibition and antimalarial properties Recent results obtained at the AlQuds University in partnership with IFBV-BELHERB from Luxembourg show that freshly prepared infusion of Artemisia annua or Artemisia afra is stronger than chloroquine in the inhibition of beta-hematin (hemozoin) formation. In infected erythrocytes, the malaria parasite generates large quantities of toxic ferri-heme, the Achille’s heel of Plasmodium. With hydrogen peroxyde which is present in all living beings, heme forms aggressive radicals which kill...

Posté dans Informations

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Citation

L’homme nous passionne, sa diversité, ses histoires, ses savoirs, ses ignorances, sa compréhension du monde

Alexandre Poussin

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