Informations

05juillet

malaria and hemozoin: hate or love

…or the key of malaria transmission.

Already 25 years ago it was known that malaria pigment (hemozoin, Hz, biocrystallized heme) is not an inert material. Crude pigment, as present in infected erythrocytes and shed after schizont rupture, may be considered the 'natural diet' ingested by macrophages in infected blood. Hemozoin is a powerful source of radicals, necrosis factor-alpha, interleukins 1 and 6. Arese P, Schwarzer E. Malarial pigment (haemozoin): a very active 'inert' substance. Ann Trop Med Parasitol. 1997 Jul;91(5):501-16. doi: 10.1080/00034989760879. PMID:...

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19juin

Piperaquine, recrudescence and gametocytes

If piperaquine fails why not use Artemisia afra

Several papers indicate that piperaquine compared to other antimalarials leads to a high level of recrudescence and a higher gametocytogenesis. Gametes are even generatd by piperaquine in asymptomatic patients with low asexual parasite densities. Reuling IJ, van de Schans LA, Sauerwein RW, Bousema T. A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model. Elife. 2018 Feb 27;7:e31549. Pasay CJ, Rockett R, Sekuloski S, et al....

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15juin

Artequick fails ? Artemisia afra eradicates malaria !

Là où les pilules échouent, Artemisia afra réussit

Submitted by Pascal Gisenya and Pierre Lutgen on 12/06/2021 In 2014, the blog « Artequick programmed for failure » on www.malariaworld.org had started a heated debate. Meanwhile several mass drug administration trials have failed, the largest one performed in the Comoros by a Chinese company. This does not prevent other people to use Africans as guinea pigs for further mass drug administration trials with the same ACTs. Okebe, J., Dabira, E., Jaiteh, F. Koen Peeters Grietens & Umberto D’Alessandro. Reactive, self-administered...

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15juin

Artequick fails ? Artemisia afra eradicates malaria !

Là où les pilules échouent, Artemisia afra réussit

Submitted by Pascal Gisenya and Pierre Lutgen on 12/06/2021 In 2014, the blog « Artequick programmed for failure » on www.malariaworld.org had started a heated debate. Meanwhile several mass drug administration trials have failed, the largest one performed in the Comoros by a Chinese company. This does not prevent other people to use Africans as guinea pigs for further mass drug administration trials with the same ACTs. Okebe, J., Dabira, E., Jaiteh, F. Koen Peeters Grietens & Umberto D’Alessandro. Reactive, self-administered...

Posté dans Informations

01juin

Malaria, tuberculosis, pneumonia and hemozoin

Breaking news: Artemisia afra cures tuberculosis

Pascal Gisenya, Nsengiyumva Bati Daddy, Jérôme Munyangi, Mutaz Akkawi, Pierre Lutgen Already 30 years ago it was known that human monocytes which have ingested hemozoin are unable to neutralize pathogenic bacteria, fungi, and tumor cells, and that macrophage responses decline during the course of human and animal malaria. Hemozoin (Hz) is a biocrystal synthesized by Plasmodium and other blood-feeding parasites to avoid the toxicity of free heme derived from the digestion of hemoglobin during invasion of the erythrocytes. Schwarzer...

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Citation

L’homme nous passionne, sa diversité, ses histoires, ses savoirs, ses ignorances, sa compréhension du monde

Alexandre Poussin

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