Informations

03septembre

Artesunate IV injections may kill

Les dangers de l'artesunate intraveineux

Oral monotherapy has been banned by WHO, but parenteral monotherapy therapy in accordance with the 2010 World Health Organization Guidelines is again recommended in case of severe malaria. Artemisinin derivatives not only lead to resistance, widespread in Africa now. N Van Hong and U. d’Alessandro describe the case of a man with severe malaria who does not respond to intravenous artesunate. Van Hong N, Amambua-Ngwa A, Tuan NQ, Cuong DD, Giang NTH, Van Dung N, U d’Alessandro. Severe malaria not responsive to artemisinin derivatives...

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03septembre

Widespread resistance to ACTs in Africa

Résistance alarmante à l'artemisinine en Afrique

Over the last century all monotherapies (quinine, chloroquine, mefloquine, lumefantrine, piperaquine, pyrimethamine, halofantrine) have lead to rapid resistances of Plasmodium falciparum. Combination therapy betweeen artemisinin and molecules with long lasting action had raised optimism. But already in 2003 first signs of resistance developed in South-East Asia. It has been established meanwhile that they were mostly related to mutations in the kelch13 propeller region of the parasite. Mutations have meanwhile raised to 90%. Timothy J.C....

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02septembre

Artemisia afra blocks, artesunate increases transmission

Artemisinin combined therapy augmente la transmission

A recent paper from Mali is alarming. Abdoulaye A. Djimde, Amelia W. Maiga, Dinkorma, Ouologuem, Bakary Fofana, Issaka Sagara, Demba Dembele, Sekou Toure, Kassim Sanogo, Souleymane Dama, Bakary Sidibe, and Ogobara K. Doumbo. Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children. Parasite. 2016; 23: 3. doi: 10.1051/parasite/2016003. The same recrudescence with oral artemisinin monotherapy had already been observed in Vietnam in 2001. P T Giao, T Q Binh, P A Kager, H...

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02septembre

High solubility and stability of artemisinin in aqueous infusions

L'artemisinine est soluble et stable dans l'eau

For 30 years, it was claimed that Artemisia annua tea infusions could not be used as remedy because artemisinin was barely soluble in water. The “WHO Position Statement on Effectiveness of Non-tablet Forms of Artemisia annua L against Malaria “, present for long years on the WHO site, not dated, not signed, not refenced, bluntly states: “it is virtually impossible for a tea bag to contain the amount of substance required to cure malaria. Artemisinin … is unstable when heated. Boiling water to make tea may cause it to lose any...

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02septembre

PCR genotyping: reliable or misleading

ACT: des doutes sur le PCR

PCR genotyping: reliable or misleading? A press release from Wellcome Trust Sanger Institute raised a lot of concern. Based on a scientific paper published in Nature Magnus Manske, Olivo Miotto, Susana Campino, Sarah Auburn, Jacob Almagro-Garcia, Gareth Maslen, Jack O’Brien, Abdoulaye Djimde, Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487, 375–379, 19 July 2012 doi:10.1038/nature11174 Studies from 2009 already asked the same question. Juliano JJ, Gadalla N, Sutherland CJ,...

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Citation

L’homme nous passionne, sa diversité, ses histoires, ses savoirs, ses ignorances, sa compréhension du monde

Alexandre Poussin

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