Cerabral malaria, interleukin 10, nitric oxide

Artemisia cerebral malaria

Several papers published twenty, even thirty years ago should have attracted more attention. In 1992 it was found that interleukin IL-10, in a dose-dependent manner, inhibits the microbicidal activity of macrophages against intracellular Toxoplasma gondii as well as the extracellular killing of schistosomula of Schistosoma mansoni. This suppression correlates with the inhibition by IL-10 of the production of toxic nitrogen oxide metabolites, an effector mechanism previously implicated in the killing by macrophages of both parasite...

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Artemisia plants contain essential oils

Monoterpenes in Artemisia

Essential oils of Artemisia plants The essential oils of Artemisia annua have been extensively studied and the major constituents are cineole, camphene, a-pinene, germacrene, caryophyllene, camphor and artemisia ketone. They are present at concentrations of 0.20-0.25% and have shown not only different antimicrobial activities, but also anti-inflammatory and cytotoxic activities1. They are reduced by high drying temperatures of the herb. Artemisia ketone is a major constituent of some cultivars of A. annua. Like other ketones it inhibits...

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Artemisia is prophylactic against malaria


ARTAVOL from Uganda PGs are important soluble mediators involved in the immune response to invading pathogens and this may explain the strong prophylactic effect of ARTAVOL, a drug developed by Dr Patrick Ogwang from the University of Makerere and the Ministry of Health in Uganda. The powder contains lemongrass (Cymbopogon citratus), avocado (Persea americana) and Artemisia annua. Avocados contain 9% of fatty acids and 71 % of these are monounsaturated. The fatty acid of lemongrass is very rich in linoleic and oleic acid. Linoleic acid...

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Malaria therapy and prophylaxy with unsaturated fatty acids

PUFA Malaria

Artemisia plants are rich in polyunsaturated fatty acids (PUFA) which generate prostaglandins and stimulate monocytes. PUFAs possess well documented antimalarial and prophylactic properties. Their half-life in plasma is several days and in adipose tissue several weeks. This may explain the prophylactic effect of regular consumption of Artemisia infusion or powder. Fish oils rich in polyunsaturated fatty acids (PUFAs) cause a marked in vitro growth inhibition of Plasmodia. Similar effects were seen in vivo on mice infected with...

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Fish oil against malaria

Arginine nitric oxide

In 1957 the University of London found that dietary cod liver oil suppressed the multiplication of Plasmodium berghei in mice D.G. Godfrey, Antiparasitic action of dietary cod liver oil upon Plasmodium berghei and its reversal by vitamin “E” Experimental Parasitology Volume 6, Issue 6, November 1957, Pages 555-56 of Babesia rodhaini D.G Godfrey The influence of dietary cod liver oil and vitamin E upon Babesia rodhaini in mice Experimental Parasitology Volume 6, Issue 6, November 1957, Pages 555-565 and on Trypanosoma...

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