PCR genotyping: reliable or misleading?
A press release from Wellcome Trust Sanger Institute raised a lot of concern. Based on a scientific paper published in Nature
Magnus Manske, Olivo Miotto, Susana Campino, Sarah Auburn, Jacob Almagro-Garcia, Gareth Maslen, Jack O’Brien, Abdoulaye Djimde, Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487, 375–379, 19 July 2012 doi:10.1038/nature11174
Studies from 2009 already asked the same question.
Juliano JJ, Gadalla N, Sutherland CJ,...