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Blood of Plasmodium falciparum-infected persons contains large quantities of uric acid precipitates. Uric acid precipitates are highly inflammatory molecules that are considered a danger signal for innate immunity and are the causative agent of gout. Uric acid may also be beneficial: it has an extraordinary ability to scavenge radicals in the plasma and extracellular environment protecting cells from external oxidative stress. Entry of uric acid into the cells has an opposite pro-oxidant effect.
Sautin YY, Johnson RJ, Uric acid:...
