Oral monotherapy has been banned by WHO, but parenteral monotherapy therapy in accordance with the 2010 World Health Organization Guidelines is again recommended in case of severe malaria.
Artemisinin derivatives not only lead to resistance, widespread in Africa now. N Van Hong and U. d’Alessandro describe the case of a man with severe malaria who does not respond to intravenous artesunate.
Van Hong N, Amambua-Ngwa A, Tuan NQ, Cuong DD, Giang NTH, Van Dung N, U d’Alessandro. Severe malaria not responsive to artemisinin derivatives...
